Predict future development of type 1 diabetes in asymptomatic children, adolescents, and young adults, when used together with family history, HLA typing, and other autoantibodies, including GD65S/glutamic acid decarboxylase (GAD65) antibody assay, Anti-antigen 2 (IA-2) serum and islet cell antibodies.
Differential diagnosis of type 1 diabetes versus type 2 diabetes.
Evaluation of diabetics with insulin resistance in patients with diabetes (type 1 or type 2).
Investigation of hypoglycemia in non-diabetic subjects.

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