What is undifferentiated pleomorphic sarcoma?

3 November 2023

It is a low-incidence oncological disease that initially occurs in the soft tissues of the body, especially in the arms or legs, as well as in the back of the abdominal organs.

Undifferentiated pleomorphic sarcoma gets its name from the way cancer cells behave under the microscope, as they are different from the body tissues in which they develop and grow in various shapes and sizes.

Although the direct cause of the cellular mutation that causes undifferentiated pleomorphic sarcoma is unknown, some development risks have been determined, such as:

Age, since it is more common in adults over 50 years old, although it can occur at any time.
Previous radiation therapy treatments.

Signs and symptoms Undifferentiated pleomorphic sarcoma

The symptoms depend on the area in which the tumor is located, generally occurring in the arms and legs, manifesting the following:

Nodule, tumor, lump, or swollen area.
Pain.
Numbness.
Swelling in the hand or foot of the affected limb.

If the sarcoma occurs in the abdominal area, there may be:

Pain.
Constipation.
High fever.
Lack of appetite.
Decreased body weight.

Diagnosis and treatment Undifferentiated pleomorphic sarcoma

The specialist, in addition to analyzing your clinical history and symptoms, will perform a physical examination in which they will pay special attention to the affected area to try to detect the size and depth of the tumor, as well as identify if it is connected to nearby tissues and if there is inflammation or damage to the nerves. Also, the following tests will be requested to confirm the diagnosis and rule out any other anomaly:

Tissue biopsy.
X-rays.
MRI.
Computed tomography.
Positron emission tomography.

Undifferentiated pleomorphic sarcoma treatment depends on where the tumor is located, but usually includes:

Medication.
Chemotherapy.
Radiation therapy.
Immunotherapy.
Surgery.

Since its inauguration in 2009, our Cancer Center has offered chemotherapy and radiation therapy treatments at the level of the best medical centers in the world through a comprehensive care model for cancer patients.

Related centers and departments Undifferentiated pleomorphic sarcoma

Cancer Center
High Specialty Surgery Center
Radiology and Molecular Imaging
Clinical Laboratory

Fuentes:

cancer.gov
cancer.org
cancer.net
ecancer.org
elsevier.es
mayoclinic.org
msdmanuals.com
medigraphic.com
Dávila-Zablah Y, Garza-García N, Garza-Montemayor ML. Sarcoma pleomórfico indiferenciado: un sarcoma excepcional en la glándula mamaria. Presentación de un caso. Annals of Radiology Mexico. 2016;15(1):70-75.
Montemayor-Sánchez D, Robles-Atayde JA, Reynoso Rivera-Río LR, et al. Manejo quirúrgico de sarcoma pleomórfico de pared abdominal. Case report. Cir Plast. 2015;25(1):23-28.

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The dissemination of the content of this material is for informational purposes only and does not replace, under any circumstance or condition, a consultation with a specialist doctor, for which the ABC Medical Center is not responsible for the different use that may be given to it. If you require more information related to the subject, we suggest you contact the specialist doctor you trust directly.

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Comparison of COVID-19 vaccines

Pfizer-
BioNTech

Pfizer-BioNTech

What is its effectiveness and what does it refer to?

Vaccine type: mRNA
Effectiveness: 95% after the second dose in the prevention of symptomatic COVID-19.

No Does not contain egg, latex, or preservatives.

How many doses are needed?
Two doses are needed, at least 21 days apart (or up to six weeks apart, if necessary).

Who should or shouldn’t get the vaccine?
People who should receive the vaccine are those over 16 years old.
People who should not receive the vaccine are those who have a history of anaphylactic shock (severe allergy) or who are allergic to any component of this vaccine such as polyethylene glycol (PEG) or polysorbate.

What are the possible side effects of the vaccine?
Pain where the injection was given, fatigue, headache, muscle pain, chills, joint pain, fever, nausea, malaise, and swollen lymph nodes.

How long will it take for me to be protected and what does it protect me from?
After 14 days of having the complete scheme (after the administration of the 2nd dose), the protection period is still under study. It protects us from serious COVID-19 or requiring hospitalization.

Moderna

What is its effectiveness and what does it refer to?

Vaccine type: mRNA
Effectiveness: 94.5% after the second dose in the prevention of symptomatic COVID-19.

Does not contain egg, latex, or preservatives.

How many doses are needed?
Two doses are needed, at least 28 days apart (or up to six weeks apart, if necessary).

Who should or shouldn’t get the vaccine?
People who should receive the vaccine are those over 18 years old.
People who should not receive the vaccine are those who have a history of anaphylactic shock (severe allergy) or who are allergic to any component of this vaccine.

What are the possible side effects of the vaccine?
Pain where the injection was given, fatigue, headache, muscle pain, chills, joint pain, fever, nausea, and swollen lymph nodes in the arm in which you received the injection.

Janssen/
Johnson
& Johnson

Janssen/ Johnson & Johnson

What is its effectiveness and what does it refer to?

Vector-based vaccine.
Effectiveness: 72.0% in the prevention of symptomatic COVID-19.
85% in the prevention of severe COVID-19.

Does not contain egg, latex, or preservatives./strong>

How many doses are needed?
Only one dose in needed.

What are the possible side effects of the vaccine?
Pain where the injection was given, headache, fatigue, muscle pain, chills, fever, and nausea.

How long will it take for me to be protected and what does it protect me from?
After 28 days of having the complete scheme (the last dose applied), the protection period is still under study. It protects us from 85% serious COVID-19 or requiring hospitalization.

AstraZeneca
and
Oxford
University

AstraZeneca and Oxford University

What is its effectiveness and what does it refer to?

Adenovirus vector-based vaccine.
Effectiveness: 82% after the second dose in the prevention of symptomatic COVID-19.

How many doses are needed?
Two doses are needed, at least 56 days apart (or up to 84 days apart, if necessary).

What are the possible side effects of the vaccine?
Pain where the injection was given, fatigue, headache, myalgia, arthralgia, and fever, which were mild to moderate in intensity and disappeared within 48 hours of vaccination.

Sputnik V

What is its effectiveness and what does it refer to?

Adenovirus vector-based vaccine.
Effectiveness: 92% after the second dose in the prevention of symptomatic COVID-19.

How many doses are needed?
Two doses are needed, at least 21 days apart (or up to six weeks apart, if necessary).

What is undifferentiated pleomorphic sarcoma?

Signs and symptoms Undifferentiated pleomorphic sarcoma

Diagnosis and treatment Undifferentiated pleomorphic sarcoma

Related centers and departments Undifferentiated pleomorphic sarcoma

Fuentes:

Index

Specialist in Undifferentiated pleomorphic sarcoma