ABC Medical Center > Monoclonal gammopathy

What is Monoclonal gammopathy?

21:56 - 4 May , 2021


It is a condition that causes the presence of an abnormal protein in the blood called monoclonal or M protein, which is located in the bone marrow. It has a higher incidence in older men.

Also known as monoclonal gammopathy of uncertain significance, this condition does not usually cause symptoms, which is why it is accidentally diagnosed in tests for other diseases, nor does it usually cause serious complications, although in some cases it can turn into myeloma or other types of blood cancer.

Those who have already been diagnosed with monoclonal gammopathy require periodic medical surveillance to monitor their evolution, and in case of showing signs of osteoporosis, they should receive treatment with bisphosphonates.

Many patients with this pathology can remain asymptomatic and without problems for decades, but there is a risk of developing serious disorders such as:

  • Multiple myeloma.
  • Macroglobulinemia.
  • B cell lymphoma.
  • Amyloidosis.
  • Osteoporosis.
  • Kidney problems.
  • Clots.

Signs and symptoms Monoclonal gammopathy

Although, in many cases there are no symptoms, in certain cases, the following may appear:

  • Rash.
  • Numbness.
  • Osteopenia.
  • Tingling.
  • Weakness.
  • Osteoporosis.
  • Bone fractures.

Diagnosis and treatment Monoclonal gammopathy

In general, being asymptomatic, monoclonal gammopathy is diagnosed by chance when performing tests for other conditions, but if there are symptoms, the doctor will request various tests to confirm the diagnosis, such as:

  • Blood and urine tests.
  • Bone densitometry.
  • MRI.
  • Computed tomography.
  • Positron emission tomography.
  • Bone marrow biopsy.

As it is normally asymptomatic and stable for long periods, monoclonal gammopathy does not need to be treated as long as it does not evolve into a dangerous disease, so the doctor will request that you undergo periodic tests to monitor the disease and your health.

At ABC Medical Center’s Internal Medicine Department, we offer health care services with the highest quality and safety, from the prevention, diagnosis, timely treatment, and monitoring of infectious, respiratory, endocrinological, dermatological, rheumatic, nephrological, gastrointestinal, and hematological pathologies of both chronic-degenerative diseases and acute conditions, through a comprehensive and multidisciplinary model.


  • Howland AI, Hernández PJC, Becherán ML, et al. Variables analíticas y clínicas en un estudio de gammapatías monoclonales. Invest Medicoquir. 2014;6(1):61-69.
  • Reibaldi AA, Sager L, Calvo R, et al. Gammapatías monoclonales de significado clínico en reumatología. Rev Cub de Reu. 2020;22(Suppl: 1):.
  • Olea-Sánchez EG, Sánchez-Moreno EC, Hernández-Salcedo DR, et al. Síndrome nefrótico por amiloidosis AL asociado con gammapatía monoclonal de cadenas ligeras lambda. Med Int Mex. 2020;36(5):722-726.
  • Pizarro R, Samanez C, Cartolin M, et al. Efecto de la medición de cadenas ligeras libres en suero en el diagnóstico de gammapatías monoclonales; experiencia en Perú. Rev Hematol Mex. 2016;17(2):99-106.

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