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Precision Medicine
4 November 2025
A bundle branch block is a blockage in which the flow of electrical impulses to the ventricles—either the left or the right—is partially or totally interrupted. These impulses are responsible for the muscular contractions that generate heartbeats. This blockage ends up making it difficult to pump blood to the rest of the body.
Depending on the damaged branch, the block can be left or right.
A bundle branch block is a condition that can occur without obvious symptoms, especially when it is not associated with other heart conditions. However, in some cases, it can cause signs such as:
A bundle branch block does not always mean the presence of a serious disease, but when it appears with other symptoms or conditions like coronary disease, hypertension, or cardiomyopathies, it can reflect a deterioration in heart function.
This can result in a reduction in the heart’s pumping efficiency, which contributes to symptoms of heart failure such as shortness of breath or swelling in the extremities.
A right bundle branch block occurs when there is an interruption or delay in electrical conduction through the right bundle branch of the His bundle. This causes the right ventricle to activate later than the left one.
This condition can be benign, especially in young and healthy people, although it can also be related to lung diseases, pulmonary embolism, or structural heart disease.
A left bundle branch block is a conduction abnormality in the left bundle branch of the heart’s conduction system, which causes a delay in the activation of the left ventricle. This results in desynchronization between the ventricles and can affect the efficiency of the heart’s pumping.
Unlike a right bundle branch block, a left bundle branch block is usually more associated with significant heart diseases such as ischemic heart disease or heart failure, so its presence generally has greater clinical relevance.
The diagnosis of a bundle branch block is made primarily through an electrocardiogram, which can identify characteristic abnormalities in the heart’s electrical conduction. Here, the key finding is the widening of the QRS complex to more than 120 milliseconds, which refers to the time in milliseconds that the ventricles take to contract.
In addition to the electrocardiogram, the doctor will evaluate the patient’s clinical history, current symptoms, and other cardiovascular risk factors to determine the possible cause of the block.
Sometimes, additional studies may be used to evaluate the structural and functional status of the heart, especially if the block is suspected to be associated with an underlying heart condition. These studies may include echocardiograms, stress tests, a cardiac MRI, or electrophysiology studies. All of these studies will help the cardiologist determine if the block is isolated and benign or if it is related to a more serious condition.
In most cases, a right bundle branch block does not require specific treatment, especially if it is considered an isolated finding and the patient does not have symptoms of another associated heart disease.
It is common for this condition to be detected incidentally on an electrocardiogram performed for routine purposes or another reason, and only periodic checkups with the cardiologist are indicated.
But if the right bundle branch block appears with other conditions, the underlying cause must be treated.
A left bundle branch block has greater clinical implications because it is often associated with structural heart diseases. Here, the treatment focuses primarily on the underlying disease.
On the other hand, if this block causes a significant desynchronization in the contraction of the ventricles and the patient has symptoms or a reduced ejection fraction, a cardiac resynchronization therapy may be indicated. This is a device similar to a pacemaker that helps improve the coordination of the heartbeat and the function of the heart.
Medications may also be required to control blood pressure, prevent cardiovascular events, and manage heart failure.
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Comparison of COVID-19 vaccines
Pfizer-
BioNTech
Pfizer-BioNTech
What is its effectiveness and what does it refer to?
Vaccine type: mRNA
Effectiveness: 95% after the second dose in the prevention of symptomatic COVID-19.
No Does not contain egg, latex, or preservatives.
How many doses are needed?
Two doses are needed, at least 21 days apart (or up to six weeks apart, if necessary).
Who should or shouldn’t get the vaccine?
People who should receive the vaccine are those over 16 years old.
People who should not receive the vaccine are those who have a history of anaphylactic shock (severe allergy) or who are allergic to any component of this vaccine such as polyethylene glycol (PEG) or polysorbate.
What are the possible side effects of the vaccine?
Pain where the injection was given, fatigue, headache, muscle pain, chills, joint pain, fever, nausea, malaise, and swollen lymph nodes.
How long will it take for me to be protected and what does it protect me from?
After 14 days of having the complete scheme (after the administration of the 2nd dose), the protection period is still under study. It protects us from serious COVID-19 or requiring hospitalization.
Moderna
What is its effectiveness and what does it refer to?
Vaccine type: mRNA
Effectiveness: 94.5% after the second dose in the prevention of symptomatic COVID-19.
Does not contain egg, latex, or preservatives.
How many doses are needed?
Two doses are needed, at least 28 days apart (or up to six weeks apart, if necessary).
Who should or shouldn’t get the vaccine?
People who should receive the vaccine are those over 18 years old.
People who should not receive the vaccine are those who have a history of anaphylactic shock (severe allergy) or who are allergic to any component of this vaccine.
What are the possible side effects of the vaccine?
Pain where the injection was given, fatigue, headache, muscle pain, chills, joint pain, fever, nausea, and swollen lymph nodes in the arm in which you received the injection.
How long will it take for me to be protected and what does it protect me from?
After 14 days of having the complete scheme (after the administration of the 2nd dose), the protection period is still under study. It protects us from serious COVID-19 or requiring hospitalization.
Janssen/
Johnson
& Johnson
Janssen/ Johnson & Johnson
What is its effectiveness and what does it refer to?
Vector-based vaccine.
Effectiveness: 72.0% in the prevention of symptomatic COVID-19.
85% in the prevention of severe COVID-19.
Does not contain egg, latex, or preservatives./strong>
How many doses are needed?
Only one dose in needed.
Who should or shouldn’t get the vaccine?
People who should receive the vaccine are those over 18 years old.
People who should not receive the vaccine are those who have a history of anaphylactic shock (severe allergy) or who are allergic to any component of this vaccine.
What are the possible side effects of the vaccine?
Pain where the injection was given, headache, fatigue, muscle pain, chills, fever, and nausea.
How long will it take for me to be protected and what does it protect me from?
After 28 days of having the complete scheme (the last dose applied), the protection period is still under study. It protects us from 85% serious COVID-19 or requiring hospitalization.
AstraZeneca
and
Oxford
University
AstraZeneca and Oxford University
What is its effectiveness and what does it refer to?
Adenovirus vector-based vaccine.
Effectiveness: 82% after the second dose in the prevention of symptomatic COVID-19.
How many doses are needed?
Two doses are needed, at least 56 days apart (or up to 84 days apart, if necessary).
Who should or shouldn’t get the vaccine?
People who should receive the vaccine are those over 18 years old.
People who should not receive the vaccine are those who have a history of anaphylactic shock (severe allergy) or who are allergic to any component of this vaccine.
What are the possible side effects of the vaccine?
Pain where the injection was given, fatigue, headache, myalgia, arthralgia, and fever, which were mild to moderate in intensity and disappeared within 48 hours of vaccination.
How long will it take for me to be protected and what does it protect me from?
After 14 days of having the complete scheme (after the administration of the 2nd dose), the protection period is still under study. It protects us from serious COVID-19 or requiring hospitalization.
Sputnik V
What is its effectiveness and what does it refer to?
Adenovirus vector-based vaccine.
Effectiveness: 92% after the second dose in the prevention of symptomatic COVID-19.
How many doses are needed?
Two doses are needed, at least 21 days apart (or up to six weeks apart, if necessary).
Who should or shouldn’t get the vaccine?
People who should receive the vaccine are those over 18 years old.
People who should not receive the vaccine are those who have a history of anaphylactic shock (severe allergy) or who are allergic to any component of this vaccine.
What are the possible side effects of the vaccine?
Pain where the injection was given, fatigue, headache, myalgia, arthralgia, and fever, which were mild to moderate in intensity and disappeared within 48 hours of vaccination.
How long will it take for me to be protected and what does it protect me from?
After 14 days of having the complete scheme (after the administration of the 2nd dose), the protection period is still under study. It protects us from serious COVID-19 or requiring hospitalization.
Anti-Herpes Zoster
Herpes zoster is a painful, burning rash. It usually appears on one part of the body and can last for several weeks. It can cause long-lasting severe pain and scarring. Bacterial skin infections, weakness, muscle paralysis, hearing or vision loss may occur less frequently. Herpes zoster is caused by the same virus that causes chickenpox. After you have had chickenpox, the virus that caused it remains in the body of nerve cells. Sometimes after many years, the virus becomes active again and causes herpes zoster.
Vaccination is indicated in the following cases:
Scheme type:
Rabies
Human rabies is a viral disease transmitted by the bite of an infected animal. It is characterized by acute encephalomyelitis (an aggressive response of the immune system that destroys the myelin layer of the nerves and alters its function at the level of the brain or spinal cord).
Vaccination is indicated in the following cases:
Scheme type:
There are two types.
1. Pre-exposure scheme, consists of three doses of rabies vaccine:
2. Post-exposure scheme, people not vaccinated against rabies, consists of five doses of rabies vaccine.
* If the individual continues to be at risk of exposure to the disease, revaccination should be considered.
Pneumococcal vaccines
Pneumococcal disease can cause serious infections in the lungs (pneumonia), the bloodstream (bacteremia), and the lining of the brain and spinal cord (meningitis).
Two vaccines help prevent pneumococcal disease:
Vaccination is indicated in the following cases:
Scheme type:
*One dose of Pneumococcal 13 vaccine should be given first, followed by one dose of Pneumococcal 23 vaccine, depending on your age and health.