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Precision Medicine
What is asplenia?
21 November 2025
Asplenia is a rare condition characterized by the absence of the spleen. The spleen is an organ located in the upper-left part of the abdomen, beneath the rib cage, that is responsible for producing antibodies to fight infections.
Asplenia is classified as:
Congenital:
- A component of heterotaxy syndrome that affects organs in the chest and abdomen.
- It can also be inherited from one of the parents.
Functional:
A disease that affects the spleen’s functionality due to:
- Atrophy
- Congestion
- Infarction
- Infiltration
Acquired:
- Surgical removal of the spleen due to injury or an enlarged spleen.
- Ruptured spleen.
With asplenia, there is a greater risk of contracting bacterial or viral infections, so administering vaccines and antibiotics is essential to prevent microorganisms from attacking the body.
Most people without a spleen lead normal, active lives, but there is always a risk of infection because, as mentioned, the spleen is a crucial part of the body’s immune system that helps fight off infections.
Diagnosis and treatment Asplenia
In addition to performing a physical exam and reviewing the patient’s medical history, the doctor will order various studies to assess the state of the spleen, including:
- X-rays
- MRI
- CT scan
The treatment for asplenia, once its origin is determined, consists of a series of measures to help avoid the risk of a severe or life-threatening infection:
- Pneumonia vaccines
- Flu vaccines
- Meningitis vaccines
- Shingles vaccines
- Chickenpox vaccines
- Preventive antibiotics
- Prophylaxis
At the ABC Medical Center’s Department of Internal Medicine, we provide high-quality, safe medical care, from prevention and diagnosis to timely treatment and follow-up for infectious, respiratory, endocrine, dermatological, rheumatic, nephrological, gastrointestinal, and hematological conditions, treating both chronic and acute illnesses through a comprehensive and multidisciplinary model.
Related centers and departments Asplenia
Fuentes:
- elsevier.es
- aeped.es
- cun.es
- analesdepediatria.org
- mayoclinic.org
- medlineplus.gov
- msdmanuals.com
- medigraphic.com
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