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Precision Medicine
4 November 2025
Coronary artery disease (CAD), also known as ischemic heart disease, is the result of cholesterol buildup in the coronary arteries. This cholesterol becomes a hard plaque that sticks to the artery walls, reducing blood circulation and the amount of oxygen supplied to the heart, which can lead to a heart attack.
In CAD, blood flow to the heart muscle is reduced. This condition can develop slowly, so symptoms may be subtle, though some people may experience them suddenly.
The main symptoms include:
There are several risk factors for coronary artery disease that can significantly increase the chances of developing this condition.
These factors include medical conditions and lifestyle habits that negatively affect the health of the arteries and the heart in general.
Some of these risk factors can be modified through lifestyle changes or medical treatment, but other factors, such as age or family history, cannot be changed and therefore must be considered for a proper assessment of cardiovascular risk. The most common risk factors include:
The diagnosis of coronary artery disease requires a comprehensive clinical evaluation that begins with the patient’s medical history and the identification of risk factors such as hypertension, diabetes, or smoking.
Likewise, it is important to identify typical symptoms like angina pectoris and dyspnea, especially during physical exertion.
A physical examination and initial tests such as a resting electrocardiogram, blood tests, and stress tests are essential to evaluate heart function and detect possible signs of ischemia.
Subsequently, imaging studies such as a cardiac echocardiogram, a coronary CT scan, or a cardiac MRI may be requested to confirm the diagnosis and determine the severity of the disease.
A coronary angiography is a procedure that can be used in cases where clinical suspicion is high but test results are inconclusive, as it allows for a direct visualization of the coronary arteries to locate significant blockages.
The goal of treatment for coronary artery disease is to improve blood flow to the heart, relieve symptoms, and prevent serious complications, such as heart attacks, thereby improving the patient’s quality of life.
Depending on the severity of the disease, treatment may begin with lifestyle changes and the use of medications to help control conditions like blood pressure, reduce cholesterol, and prevent the formation of blood clots.
For more advanced cases, or in those people whose symptoms do not improve with medication, more invasive medical interventions may be required. One of the most common options is a coronary angioplasty, which is the placement of a stent to open blocked arteries. Another procedure that may be required is coronary bypass surgery, which redirects blood flow around blocked arteries.
Regardless of the type of treatment needed, continuous medical follow-up and cardiac rehabilitation are key components for maintaining control of the disease and reducing the risk of future cardiovascular events.
The prevention of coronary artery disease is mainly based on adopting measures to lead a healthy lifestyle and control known risk factors.
A balanced diet that includes fruits, vegetables, whole grains, and is low in saturated fats and sugars is essential for maintaining cardiovascular health.
It’s also important to get regular physical activity, with at least 150 minutes per week of moderate exercise. This helps strengthen the cardiovascular system, control weight, and reduce blood pressure.
It is essential to avoid tobacco use and moderate alcohol consumption, as these habits are highly related to arterial damage, as well as other heart and general health problems.
Controlling existing diseases, such as hypertension, diabetes, or high cholesterol, through regular medical checkups and adherence to the proper treatment also plays a crucial role.
Good education about cardiovascular health and the early recognition of symptoms can make a difference in preventing serious complications.
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Comparison of COVID-19 vaccines
Pfizer-
BioNTech
Pfizer-BioNTech
What is its effectiveness and what does it refer to?
Vaccine type: mRNA
Effectiveness: 95% after the second dose in the prevention of symptomatic COVID-19.
No Does not contain egg, latex, or preservatives.
How many doses are needed?
Two doses are needed, at least 21 days apart (or up to six weeks apart, if necessary).
Who should or shouldn’t get the vaccine?
People who should receive the vaccine are those over 16 years old.
People who should not receive the vaccine are those who have a history of anaphylactic shock (severe allergy) or who are allergic to any component of this vaccine such as polyethylene glycol (PEG) or polysorbate.
What are the possible side effects of the vaccine?
Pain where the injection was given, fatigue, headache, muscle pain, chills, joint pain, fever, nausea, malaise, and swollen lymph nodes.
How long will it take for me to be protected and what does it protect me from?
After 14 days of having the complete scheme (after the administration of the 2nd dose), the protection period is still under study. It protects us from serious COVID-19 or requiring hospitalization.
Moderna
What is its effectiveness and what does it refer to?
Vaccine type: mRNA
Effectiveness: 94.5% after the second dose in the prevention of symptomatic COVID-19.
Does not contain egg, latex, or preservatives.
How many doses are needed?
Two doses are needed, at least 28 days apart (or up to six weeks apart, if necessary).
Who should or shouldn’t get the vaccine?
People who should receive the vaccine are those over 18 years old.
People who should not receive the vaccine are those who have a history of anaphylactic shock (severe allergy) or who are allergic to any component of this vaccine.
What are the possible side effects of the vaccine?
Pain where the injection was given, fatigue, headache, muscle pain, chills, joint pain, fever, nausea, and swollen lymph nodes in the arm in which you received the injection.
How long will it take for me to be protected and what does it protect me from?
After 14 days of having the complete scheme (after the administration of the 2nd dose), the protection period is still under study. It protects us from serious COVID-19 or requiring hospitalization.
Janssen/
Johnson
& Johnson
Janssen/ Johnson & Johnson
What is its effectiveness and what does it refer to?
Vector-based vaccine.
Effectiveness: 72.0% in the prevention of symptomatic COVID-19.
85% in the prevention of severe COVID-19.
Does not contain egg, latex, or preservatives./strong>
How many doses are needed?
Only one dose in needed.
Who should or shouldn’t get the vaccine?
People who should receive the vaccine are those over 18 years old.
People who should not receive the vaccine are those who have a history of anaphylactic shock (severe allergy) or who are allergic to any component of this vaccine.
What are the possible side effects of the vaccine?
Pain where the injection was given, headache, fatigue, muscle pain, chills, fever, and nausea.
How long will it take for me to be protected and what does it protect me from?
After 28 days of having the complete scheme (the last dose applied), the protection period is still under study. It protects us from 85% serious COVID-19 or requiring hospitalization.
AstraZeneca
and
Oxford
University
AstraZeneca and Oxford University
What is its effectiveness and what does it refer to?
Adenovirus vector-based vaccine.
Effectiveness: 82% after the second dose in the prevention of symptomatic COVID-19.
How many doses are needed?
Two doses are needed, at least 56 days apart (or up to 84 days apart, if necessary).
Who should or shouldn’t get the vaccine?
People who should receive the vaccine are those over 18 years old.
People who should not receive the vaccine are those who have a history of anaphylactic shock (severe allergy) or who are allergic to any component of this vaccine.
What are the possible side effects of the vaccine?
Pain where the injection was given, fatigue, headache, myalgia, arthralgia, and fever, which were mild to moderate in intensity and disappeared within 48 hours of vaccination.
How long will it take for me to be protected and what does it protect me from?
After 14 days of having the complete scheme (after the administration of the 2nd dose), the protection period is still under study. It protects us from serious COVID-19 or requiring hospitalization.
Sputnik V
What is its effectiveness and what does it refer to?
Adenovirus vector-based vaccine.
Effectiveness: 92% after the second dose in the prevention of symptomatic COVID-19.
How many doses are needed?
Two doses are needed, at least 21 days apart (or up to six weeks apart, if necessary).
Who should or shouldn’t get the vaccine?
People who should receive the vaccine are those over 18 years old.
People who should not receive the vaccine are those who have a history of anaphylactic shock (severe allergy) or who are allergic to any component of this vaccine.
What are the possible side effects of the vaccine?
Pain where the injection was given, fatigue, headache, myalgia, arthralgia, and fever, which were mild to moderate in intensity and disappeared within 48 hours of vaccination.
How long will it take for me to be protected and what does it protect me from?
After 14 days of having the complete scheme (after the administration of the 2nd dose), the protection period is still under study. It protects us from serious COVID-19 or requiring hospitalization.
Anti-Herpes Zoster
Herpes zoster is a painful, burning rash. It usually appears on one part of the body and can last for several weeks. It can cause long-lasting severe pain and scarring. Bacterial skin infections, weakness, muscle paralysis, hearing or vision loss may occur less frequently. Herpes zoster is caused by the same virus that causes chickenpox. After you have had chickenpox, the virus that caused it remains in the body of nerve cells. Sometimes after many years, the virus becomes active again and causes herpes zoster.
Vaccination is indicated in the following cases:
Scheme type:
Rabies
Human rabies is a viral disease transmitted by the bite of an infected animal. It is characterized by acute encephalomyelitis (an aggressive response of the immune system that destroys the myelin layer of the nerves and alters its function at the level of the brain or spinal cord).
Vaccination is indicated in the following cases:
Scheme type:
There are two types.
1. Pre-exposure scheme, consists of three doses of rabies vaccine:
2. Post-exposure scheme, people not vaccinated against rabies, consists of five doses of rabies vaccine.
* If the individual continues to be at risk of exposure to the disease, revaccination should be considered.
Pneumococcal vaccines
Pneumococcal disease can cause serious infections in the lungs (pneumonia), the bloodstream (bacteremia), and the lining of the brain and spinal cord (meningitis).
Two vaccines help prevent pneumococcal disease:
Vaccination is indicated in the following cases:
Scheme type:
*One dose of Pneumococcal 13 vaccine should be given first, followed by one dose of Pneumococcal 23 vaccine, depending on your age and health.