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What is lambert-eaton myasthenic syndrome?
12 December 2025
It is a low-incidence, immune disorder of the nervous system characterized by a loss of movement or muscle weakness, especially in the legs, caused by a deficiency of a chemical called acetylcholine, which is responsible for transmitting signals between nerves and muscles.
Lambert-Eaton Myasthenic Syndrome (LEMS) usually appears in old age, with the male sex being the most affected.
According to the most recent clinical research, this condition may arise in the presence of certain autoimmune disorders, such as vitiligo, or various types of cancer, including lung cancer.
Signs and symptoms Lambert-Eaton Myasthenic Syndrome
Symptoms can be mild or severe, typically including:
- Head tilting.
- Muscle weakness and pain.
- Difficulty walking, lifting things, or climbing stairs.
- Chronic fatigue or tiredness.
- Ocular disturbances, such as blurred, double vision, or difficulty focusing.
- Problems getting up from a sitting or lying position.
- Loss of movement.
- Loss of muscle tissue and mass.
- Speech disorders.
Signs related to other areas of the nervous system also appear, such as:
- Alterations in blood pressure.
- Dry mouth.
- Erectile dysfunction.
- Constipation.
- Dizziness, especially when standing up.
- Dry eyes.
The main risks that Lambert-Eaton Myasthenic Syndrome can cause are difficulty breathing and swallowing, trauma from falls, pneumonia or other infections, and coordination problems.
Diagnosis and treatment Lambert-Eaton Myasthenic Syndrome
After the doctor analyzes your symptoms and clinical history, they will perform a physical examination and request a series of tests to help confirm the diagnosis, including:
- Electromyography (EMG).
- Blood tests.
- Magnetic Resonance Imaging (MRI).
- Computed Tomography (CT scan).
- Nerve conduction velocity (NCV).
The treatment aims to alleviate the symptoms through drugs that inhibit the immune system response and increase the release of acetylcholine from nerve cells, as well as anticholinesterases to help improve muscle tone.
Additionally, plasmapheresis can be useful in the treatment of this pathology.
At the Neurology Center, a group of highly trained and certified doctors in various neurological specialties are ready to assist you with the quality and warmth that characterizes us.
Related centers and departments Lambert-Eaton Myasthenic Syndrome
Fuentes:
- neurologia.com
- neurology.org
- adam.com
- medlineplus.gov
- msdmanuals.com
- topdoctors.es
- nysora.com
- medigraphic.com
- González-Houdelath K, Varela MAC, Barrantes AGJ. Síndrome de Lambert-Eaton paraneoplásico en carcinoma de células pequeñas de pulmón. Revista Médica Sinergia. 2020;5(08):1-9.
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The dissemination of the content of this material is for informational purposes only and does not replace, under any circumstance or condition, a consultation with a specialist doctor, for which the ABC Medical Center is not responsible for the different use that may be given to it. If you require more information related to the subject, we suggest you contact the specialist doctor you trust directly.
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