What is Systemic Capillary Leak Syndrome?

It is a serious disorder characterized by the leakage of fluids and protein through the blood vessels, which causes inflammation of the tissues and a sudden drop in blood pressure that can lead to organ failure or death.

Systemic capillary leak syndrome, also known as Clarkson’s disease, can arise from an upper respiratory infection or physical overexertion, triggering hypotension, edema, or hypovolemia.

This pathology can be confused with serious reactions to generalized infections or major allergic reactions.

To date, the cause of systemic capillary leak syndrome is unknown, but clinical studies indicate that people between 45 and 55 years old are at greater risk of suffering from it.

Signs and symptoms Systemic Capillary Leak Syndrome

Weight gain.
Daze.
Fatigue.
Lack of energy.
Sore abdomen.
Muscle pain.
High fever.
Swollen body.
Irritability.
Nausea.
Excessive thirst.
Digestive disorders.
Limited urination.
Dark urine.

In the final phase, massive edema reabsorption occurs, causing excess urine and weight loss.

The greatest risk of systemic capillary leak syndrome is that by reducing blood volume and blood pressure, a lack of oxygen and basic nutrients can occur reducing the proper functionality of the brain, liver, and kidneys.

Diagnosis and treatment Systemic Capillary Leak Syndrome

It is complex to diagnose this disease, so after analyzing the symptoms and clinical history, the doctor will perform a physical examination and request tests that allow them to corroborate the diagnosis, such as:

Blood and urine tests.
X-rays.
MRI.
Computed tomography.

Systemic capillary leak syndrome has no cure, so medical treatment consists of treating the symptoms by ingesting drugs and fluids intravenously to keep blood pressure stable and prevent damage to vital organs such as the brain, heart, liver, and kidneys; as well as reduce the frequency and severity of future episodes.

In ABC Medical Center Internal Medicine Department, we provide you with health care services with the highest quality and safety, from prevention, diagnosis, timely treatment, and follow-up of infectious, respiratory, endocrinological, dermatological, rheumatic, nephrological, gastrointestinal, and hematological conditions, both chronic-degenerative and acute, through a comprehensive and multidisciplinary model.

Related centers and departments

Internal Medicine
High Specialty Surgery Center
Radiology and Molecular Imaging
Clinical Laboratory

Fuentes:

nih.gov
orpha.net
aeped.es
neumologiaysalud.es
middlesexhealth.org
mayoclinic.org
msdmanuals.com
medigraphic.com

How can we help you?

The dissemination of the content of this material is for informational purposes only and does not replace, under any circumstance or condition, a consultation with a specialist doctor, for which the ABC Medical Center is not responsible for the different use that may be given to it. If you require more information related to the subject, we suggest you contact the specialist doctor you trust directly.

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Comparison of COVID-19 vaccines

Pfizer-
BioNTech

Pfizer-BioNTech

What is its effectiveness and what does it refer to?

Vaccine type: mRNA
Effectiveness: 95% after the second dose in the prevention of symptomatic COVID-19.

No Does not contain egg, latex, or preservatives.

How many doses are needed?
Two doses are needed, at least 21 days apart (or up to six weeks apart, if necessary).

Who should or shouldn’t get the vaccine?
People who should receive the vaccine are those over 16 years old.
People who should not receive the vaccine are those who have a history of anaphylactic shock (severe allergy) or who are allergic to any component of this vaccine such as polyethylene glycol (PEG) or polysorbate.

What are the possible side effects of the vaccine?
Pain where the injection was given, fatigue, headache, muscle pain, chills, joint pain, fever, nausea, malaise, and swollen lymph nodes.

How long will it take for me to be protected and what does it protect me from?
After 14 days of having the complete scheme (after the administration of the 2nd dose), the protection period is still under study. It protects us from serious COVID-19 or requiring hospitalization.

Moderna

What is its effectiveness and what does it refer to?

Vaccine type: mRNA
Effectiveness: 94.5% after the second dose in the prevention of symptomatic COVID-19.

Does not contain egg, latex, or preservatives.

How many doses are needed?
Two doses are needed, at least 28 days apart (or up to six weeks apart, if necessary).

Who should or shouldn’t get the vaccine?
People who should receive the vaccine are those over 18 years old.
People who should not receive the vaccine are those who have a history of anaphylactic shock (severe allergy) or who are allergic to any component of this vaccine.

What are the possible side effects of the vaccine?
Pain where the injection was given, fatigue, headache, muscle pain, chills, joint pain, fever, nausea, and swollen lymph nodes in the arm in which you received the injection.

Janssen/
Johnson
& Johnson

Janssen/ Johnson & Johnson

What is its effectiveness and what does it refer to?

Vector-based vaccine.
Effectiveness: 72.0% in the prevention of symptomatic COVID-19.
85% in the prevention of severe COVID-19.

Does not contain egg, latex, or preservatives./strong>

How many doses are needed?
Only one dose in needed.

What are the possible side effects of the vaccine?
Pain where the injection was given, headache, fatigue, muscle pain, chills, fever, and nausea.

How long will it take for me to be protected and what does it protect me from?
After 28 days of having the complete scheme (the last dose applied), the protection period is still under study. It protects us from 85% serious COVID-19 or requiring hospitalization.

AstraZeneca
and
Oxford
University

AstraZeneca and Oxford University

What is its effectiveness and what does it refer to?

Adenovirus vector-based vaccine.
Effectiveness: 82% after the second dose in the prevention of symptomatic COVID-19.

How many doses are needed?
Two doses are needed, at least 56 days apart (or up to 84 days apart, if necessary).

What are the possible side effects of the vaccine?
Pain where the injection was given, fatigue, headache, myalgia, arthralgia, and fever, which were mild to moderate in intensity and disappeared within 48 hours of vaccination.

Sputnik V

What is its effectiveness and what does it refer to?

Adenovirus vector-based vaccine.
Effectiveness: 92% after the second dose in the prevention of symptomatic COVID-19.

How many doses are needed?
Two doses are needed, at least 21 days apart (or up to six weeks apart, if necessary).

What is Systemic Capillary Leak Syndrome?

Signs and symptoms Systemic Capillary Leak Syndrome

Diagnosis and treatment Systemic Capillary Leak Syndrome

Related centers and departments

Fuentes:

Index

Specialist in Systemic Capillary Leak Syndrome