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Precision Medicine
4 November 2025
Dysautonomia, or autonomic dysfunction, is a disorder of the autonomic nervous system in which automatic bodily functions like digestion, body temperature, or heart rate are affected.
The autonomic nervous system is responsible for managing and controlling various bodily functions.
Although the cause is unknown, clinical research suggests that its onset may be due to an abnormality in the sympathetic nervous system, which is in charge of normalizing the response to stress and heat, and the parasympathetic system, which is responsible for rest and relaxation.
It is also often linked to multisystem atrophy, diabetes, polyneuropathy, and Parkinson’s disease.
Dysautonomia affects women more often and is classified as:
The symptoms of dysautonomia can vary widely from person to person and depend on the specific type of dysautonomia they have.
Some of the most common symptoms related to dysautonomia include dizziness or fainting when standing up, known as orthostatic hypotension, extreme fatigue, palpitations, exercise intolerance, and gastrointestinal problems like feeling full quickly or nausea.
It’s also possible for a person with dysautonomia to experience unexplained anxiety, blurred vision, excessive or reduced sweating, difficulty regulating body temperature, which can trigger a feeling of being very cold or very hot, as well as changes in urination or bowel movements.
The presence of these symptoms can be persistent or intermittent and often worsens with stress, heat, or postural changes.
Because all of these symptoms can be related to many other conditions, this makes a diagnosis difficult, which is why a complete clinical evaluation is essential.
The diagnosis of dysautonomia can be complex due to the wide variety of symptoms and their similarity to other disorders.
It usually begins with a detailed medical history analysis and a physical exam focused on the body’s response to different postures, temperatures, efforts, and emotional states.
A tilt table test is also frequently requested. This test evaluates blood pressure and heart rate when changing position. Additionally, prolonged cardiac monitoring with a Holter monitor, or studies of sweating and heart rate variability, may be performed.
In addition, blood tests, autonomic function studies, and sometimes genetic tests may be indicated if hereditary forms are suspected.
Reaching a diagnosis of dysautonomia requires the collaboration of various specialists, such as neurologists, cardiologists, or rheumatologists, although the type of specialist will vary depending on the symptom profile.
Because there is no single conclusive test for its diagnosis, it is often reached by exclusion and is based on a comprehensive evaluation of both laboratory and clinical findings.
The treatment for dysautonomia varies depending on the underlying cause and the specific type of autonomic disorder, but generally, the treatment seeks to alleviate symptoms and improve the person’s quality of life.
Non-pharmacological measures are key and may include increasing fluid and salt intake, using compression stockings, avoiding sudden changes in position, and having smaller, more frequent meals.
It is also recommended to avoid factors that worsen symptoms, including excessive heat, stress, or alcohol consumption.
Medications may be used in some cases to control specific symptoms. These can be used to address tachycardia, orthostatic hypotension, or to regulate digestion and sweating.
Physical therapy and progressive resistance exercises can also help improve tolerance to physical exertion.
Because dysautonomia is a chronic condition, treatment is usually personalized and evolves over time, requiring continuous follow-up with healthcare professionals who are familiar with treating autonomic nervous system disorders.
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Comparison of COVID-19 vaccines
Pfizer-
BioNTech
Pfizer-BioNTech
What is its effectiveness and what does it refer to?
Vaccine type: mRNA
Effectiveness: 95% after the second dose in the prevention of symptomatic COVID-19.
No Does not contain egg, latex, or preservatives.
How many doses are needed?
Two doses are needed, at least 21 days apart (or up to six weeks apart, if necessary).
Who should or shouldn’t get the vaccine?
People who should receive the vaccine are those over 16 years old.
People who should not receive the vaccine are those who have a history of anaphylactic shock (severe allergy) or who are allergic to any component of this vaccine such as polyethylene glycol (PEG) or polysorbate.
What are the possible side effects of the vaccine?
Pain where the injection was given, fatigue, headache, muscle pain, chills, joint pain, fever, nausea, malaise, and swollen lymph nodes.
How long will it take for me to be protected and what does it protect me from?
After 14 days of having the complete scheme (after the administration of the 2nd dose), the protection period is still under study. It protects us from serious COVID-19 or requiring hospitalization.
Moderna
What is its effectiveness and what does it refer to?
Vaccine type: mRNA
Effectiveness: 94.5% after the second dose in the prevention of symptomatic COVID-19.
Does not contain egg, latex, or preservatives.
How many doses are needed?
Two doses are needed, at least 28 days apart (or up to six weeks apart, if necessary).
Who should or shouldn’t get the vaccine?
People who should receive the vaccine are those over 18 years old.
People who should not receive the vaccine are those who have a history of anaphylactic shock (severe allergy) or who are allergic to any component of this vaccine.
What are the possible side effects of the vaccine?
Pain where the injection was given, fatigue, headache, muscle pain, chills, joint pain, fever, nausea, and swollen lymph nodes in the arm in which you received the injection.
How long will it take for me to be protected and what does it protect me from?
After 14 days of having the complete scheme (after the administration of the 2nd dose), the protection period is still under study. It protects us from serious COVID-19 or requiring hospitalization.
Janssen/
Johnson
& Johnson
Janssen/ Johnson & Johnson
What is its effectiveness and what does it refer to?
Vector-based vaccine.
Effectiveness: 72.0% in the prevention of symptomatic COVID-19.
85% in the prevention of severe COVID-19.
Does not contain egg, latex, or preservatives./strong>
How many doses are needed?
Only one dose in needed.
Who should or shouldn’t get the vaccine?
People who should receive the vaccine are those over 18 years old.
People who should not receive the vaccine are those who have a history of anaphylactic shock (severe allergy) or who are allergic to any component of this vaccine.
What are the possible side effects of the vaccine?
Pain where the injection was given, headache, fatigue, muscle pain, chills, fever, and nausea.
How long will it take for me to be protected and what does it protect me from?
After 28 days of having the complete scheme (the last dose applied), the protection period is still under study. It protects us from 85% serious COVID-19 or requiring hospitalization.
AstraZeneca
and
Oxford
University
AstraZeneca and Oxford University
What is its effectiveness and what does it refer to?
Adenovirus vector-based vaccine.
Effectiveness: 82% after the second dose in the prevention of symptomatic COVID-19.
How many doses are needed?
Two doses are needed, at least 56 days apart (or up to 84 days apart, if necessary).
Who should or shouldn’t get the vaccine?
People who should receive the vaccine are those over 18 years old.
People who should not receive the vaccine are those who have a history of anaphylactic shock (severe allergy) or who are allergic to any component of this vaccine.
What are the possible side effects of the vaccine?
Pain where the injection was given, fatigue, headache, myalgia, arthralgia, and fever, which were mild to moderate in intensity and disappeared within 48 hours of vaccination.
How long will it take for me to be protected and what does it protect me from?
After 14 days of having the complete scheme (after the administration of the 2nd dose), the protection period is still under study. It protects us from serious COVID-19 or requiring hospitalization.
Sputnik V
What is its effectiveness and what does it refer to?
Adenovirus vector-based vaccine.
Effectiveness: 92% after the second dose in the prevention of symptomatic COVID-19.
How many doses are needed?
Two doses are needed, at least 21 days apart (or up to six weeks apart, if necessary).
Who should or shouldn’t get the vaccine?
People who should receive the vaccine are those over 18 years old.
People who should not receive the vaccine are those who have a history of anaphylactic shock (severe allergy) or who are allergic to any component of this vaccine.
What are the possible side effects of the vaccine?
Pain where the injection was given, fatigue, headache, myalgia, arthralgia, and fever, which were mild to moderate in intensity and disappeared within 48 hours of vaccination.
How long will it take for me to be protected and what does it protect me from?
After 14 days of having the complete scheme (after the administration of the 2nd dose), the protection period is still under study. It protects us from serious COVID-19 or requiring hospitalization.
Anti-Herpes Zoster
Herpes zoster is a painful, burning rash. It usually appears on one part of the body and can last for several weeks. It can cause long-lasting severe pain and scarring. Bacterial skin infections, weakness, muscle paralysis, hearing or vision loss may occur less frequently. Herpes zoster is caused by the same virus that causes chickenpox. After you have had chickenpox, the virus that caused it remains in the body of nerve cells. Sometimes after many years, the virus becomes active again and causes herpes zoster.
Vaccination is indicated in the following cases:
Scheme type:
Rabies
Human rabies is a viral disease transmitted by the bite of an infected animal. It is characterized by acute encephalomyelitis (an aggressive response of the immune system that destroys the myelin layer of the nerves and alters its function at the level of the brain or spinal cord).
Vaccination is indicated in the following cases:
Scheme type:
There are two types.
1. Pre-exposure scheme, consists of three doses of rabies vaccine:
2. Post-exposure scheme, people not vaccinated against rabies, consists of five doses of rabies vaccine.
* If the individual continues to be at risk of exposure to the disease, revaccination should be considered.
Pneumococcal vaccines
Pneumococcal disease can cause serious infections in the lungs (pneumonia), the bloodstream (bacteremia), and the lining of the brain and spinal cord (meningitis).
Two vaccines help prevent pneumococcal disease:
Vaccination is indicated in the following cases:
Scheme type:
*One dose of Pneumococcal 13 vaccine should be given first, followed by one dose of Pneumococcal 23 vaccine, depending on your age and health.