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Precision Medicine
8 October 2025
An aneurysm is a condition that can affect any artery in the body. It appears as a balloon-like bulge in an artery due to a weakening of the arterial walls, which are pushed outward by blood pressure.
Depending on the level of dilation, an aneurysm can rupture and cause a potentially fatal hemorrhage.
Aneurysms often occur in the brain, causing a stroke that can lead to death, and in the aorta, either at the thoracic or abdominal level, with a risk of fatal cardiovascular consequences.
In the case of cerebral aneurysms, they generally appear between the brain and the tissue that covers it. When they rupture, they cause a subarachnoid hemorrhage, leading to a hemorrhagic stroke, which is a medical emergency that requires immediate attention.
Many times, cerebral aneurysms don’t rupture and have no symptoms or complications, so they are often detected by accident during studies performed for other reasons. Once detected, treatment focuses on preventing a possible rupture later on.
The direct causes of their appearance have not yet been determined, but it is known that they affect adult women more and that a number of potential risk factors have been identified as possible triggers:
In the case of congenital factors, these are associated with the presence of various conditions such as:
Depending on the size, location, and whether it is a ruptured or unruptured aneurysm, it can manifest with various clinical signs that can put the patient’s life at risk. Given this, it is crucial to be aware of the possible symptoms to achieve early detection and timely treatment.
When an aneurysm ruptures, symptoms appear suddenly and are generally intense. In the case of a ruptured cerebral aneurysm, the most characteristic sign is a sudden, unbearable headache, which is often described as “the worst headache of my life.”
This pain can be accompanied by other symptoms such as nausea, vomiting, neck stiffness, loss of consciousness, and, in some cases, seizures.
Beyond the pain, a ruptured aneurysm can also cause severe neurological changes such as double vision, light sensitivity, difficulty speaking, paralysis on one side of the body, or disorientation.
These types of symptoms reflect brain damage from a subarachnoid hemorrhage, a medical emergency that requires immediate medical attention. If there is no urgent treatment, the consequences can be devastating, including permanent brain damage or death.
An unruptured aneurysm is often a silent condition, which is detected incidentally during studies performed for another reason. However, some people may experience symptoms if the aneurysm is putting pressure on nearby structures. For example, in the case of a cerebral aneurysm, symptoms can include blurred vision or vision loss in one eye. There can also be facial or cranial pain, as well as weakening of the facial muscles.
If the aneurysm is in other locations, such as an abdominal aortic aneurysm, symptoms may be absent. But there may be a pulsating sensation in the abdomen, persistent pain in the back or abdomen, as well as discomfort that worsens when standing or straining. All of these can be a sign that the aneurysm is growing.
The diagnosis of an aneurysm begins with clinical suspicion, especially in people who already have risk factors such as hypertension, a family history, or smoking.
To reach a confirmatory diagnosis, imaging studies are used, which vary depending on the location of the aneurysm. In the case of cerebral aneurysms, a CT scan or an MRI can be performed to reveal the presence of a vascular malformation.
If a rupture is suspected, an emergency CT scan and, if necessary, a lumbar puncture are performed.
For aortic aneurysms, the most commonly used studies are abdominal ultrasound, CT scan, and angiography to evaluate the size, location, and risk of rupture.
All of these tools are also useful for planning surgical treatment and for monitoring patients with small aneurysms who don’t yet require intervention.
The treatment for aneurysms will depend on the location, size, symptoms, and risk of rupture. Sometimes, especially if the aneurysm is small and asymptomatic, medical monitoring with periodic check-ups is chosen. But if there is a risk of rupture or significant symptoms, surgical intervention is initiated.
There are two main approaches to treating an aneurysm:
The choice of treatment type should be based on the patient’s general condition, the aneurysm’s anatomy, and the available resources.
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Comparison of COVID-19 vaccines
Pfizer-
BioNTech
Pfizer-BioNTech
What is its effectiveness and what does it refer to?
Vaccine type: mRNA
Effectiveness: 95% after the second dose in the prevention of symptomatic COVID-19.
No Does not contain egg, latex, or preservatives.
How many doses are needed?
Two doses are needed, at least 21 days apart (or up to six weeks apart, if necessary).
Who should or shouldn’t get the vaccine?
People who should receive the vaccine are those over 16 years old.
People who should not receive the vaccine are those who have a history of anaphylactic shock (severe allergy) or who are allergic to any component of this vaccine such as polyethylene glycol (PEG) or polysorbate.
What are the possible side effects of the vaccine?
Pain where the injection was given, fatigue, headache, muscle pain, chills, joint pain, fever, nausea, malaise, and swollen lymph nodes.
How long will it take for me to be protected and what does it protect me from?
After 14 days of having the complete scheme (after the administration of the 2nd dose), the protection period is still under study. It protects us from serious COVID-19 or requiring hospitalization.
Moderna
What is its effectiveness and what does it refer to?
Vaccine type: mRNA
Effectiveness: 94.5% after the second dose in the prevention of symptomatic COVID-19.
Does not contain egg, latex, or preservatives.
How many doses are needed?
Two doses are needed, at least 28 days apart (or up to six weeks apart, if necessary).
Who should or shouldn’t get the vaccine?
People who should receive the vaccine are those over 18 years old.
People who should not receive the vaccine are those who have a history of anaphylactic shock (severe allergy) or who are allergic to any component of this vaccine.
What are the possible side effects of the vaccine?
Pain where the injection was given, fatigue, headache, muscle pain, chills, joint pain, fever, nausea, and swollen lymph nodes in the arm in which you received the injection.
How long will it take for me to be protected and what does it protect me from?
After 14 days of having the complete scheme (after the administration of the 2nd dose), the protection period is still under study. It protects us from serious COVID-19 or requiring hospitalization.
Janssen/
Johnson
& Johnson
Janssen/ Johnson & Johnson
What is its effectiveness and what does it refer to?
Vector-based vaccine.
Effectiveness: 72.0% in the prevention of symptomatic COVID-19.
85% in the prevention of severe COVID-19.
Does not contain egg, latex, or preservatives./strong>
How many doses are needed?
Only one dose in needed.
Who should or shouldn’t get the vaccine?
People who should receive the vaccine are those over 18 years old.
People who should not receive the vaccine are those who have a history of anaphylactic shock (severe allergy) or who are allergic to any component of this vaccine.
What are the possible side effects of the vaccine?
Pain where the injection was given, headache, fatigue, muscle pain, chills, fever, and nausea.
How long will it take for me to be protected and what does it protect me from?
After 28 days of having the complete scheme (the last dose applied), the protection period is still under study. It protects us from 85% serious COVID-19 or requiring hospitalization.
AstraZeneca
and
Oxford
University
AstraZeneca and Oxford University
What is its effectiveness and what does it refer to?
Adenovirus vector-based vaccine.
Effectiveness: 82% after the second dose in the prevention of symptomatic COVID-19.
How many doses are needed?
Two doses are needed, at least 56 days apart (or up to 84 days apart, if necessary).
Who should or shouldn’t get the vaccine?
People who should receive the vaccine are those over 18 years old.
People who should not receive the vaccine are those who have a history of anaphylactic shock (severe allergy) or who are allergic to any component of this vaccine.
What are the possible side effects of the vaccine?
Pain where the injection was given, fatigue, headache, myalgia, arthralgia, and fever, which were mild to moderate in intensity and disappeared within 48 hours of vaccination.
How long will it take for me to be protected and what does it protect me from?
After 14 days of having the complete scheme (after the administration of the 2nd dose), the protection period is still under study. It protects us from serious COVID-19 or requiring hospitalization.
Sputnik V
What is its effectiveness and what does it refer to?
Adenovirus vector-based vaccine.
Effectiveness: 92% after the second dose in the prevention of symptomatic COVID-19.
How many doses are needed?
Two doses are needed, at least 21 days apart (or up to six weeks apart, if necessary).
Who should or shouldn’t get the vaccine?
People who should receive the vaccine are those over 18 years old.
People who should not receive the vaccine are those who have a history of anaphylactic shock (severe allergy) or who are allergic to any component of this vaccine.
What are the possible side effects of the vaccine?
Pain where the injection was given, fatigue, headache, myalgia, arthralgia, and fever, which were mild to moderate in intensity and disappeared within 48 hours of vaccination.
How long will it take for me to be protected and what does it protect me from?
After 14 days of having the complete scheme (after the administration of the 2nd dose), the protection period is still under study. It protects us from serious COVID-19 or requiring hospitalization.
Anti-Herpes Zoster
Herpes zoster is a painful, burning rash. It usually appears on one part of the body and can last for several weeks. It can cause long-lasting severe pain and scarring. Bacterial skin infections, weakness, muscle paralysis, hearing or vision loss may occur less frequently. Herpes zoster is caused by the same virus that causes chickenpox. After you have had chickenpox, the virus that caused it remains in the body of nerve cells. Sometimes after many years, the virus becomes active again and causes herpes zoster.
Vaccination is indicated in the following cases:
Scheme type:
Rabies
Human rabies is a viral disease transmitted by the bite of an infected animal. It is characterized by acute encephalomyelitis (an aggressive response of the immune system that destroys the myelin layer of the nerves and alters its function at the level of the brain or spinal cord).
Vaccination is indicated in the following cases:
Scheme type:
There are two types.
1. Pre-exposure scheme, consists of three doses of rabies vaccine:
2. Post-exposure scheme, people not vaccinated against rabies, consists of five doses of rabies vaccine.
* If the individual continues to be at risk of exposure to the disease, revaccination should be considered.
Pneumococcal vaccines
Pneumococcal disease can cause serious infections in the lungs (pneumonia), the bloodstream (bacteremia), and the lining of the brain and spinal cord (meningitis).
Two vaccines help prevent pneumococcal disease:
Vaccination is indicated in the following cases:
Scheme type:
*One dose of Pneumococcal 13 vaccine should be given first, followed by one dose of Pneumococcal 23 vaccine, depending on your age and health.